Destron Gas is created by four machines on Earth, that are all destroyed by the Z Fighters. In Plan to Eradicate the Super Saiyans, the four machines are located in Diablo Desert, Satan City, Jingle Village, and West City, while in the original version they are at Grand Apron, the Western Desert, Poco Poco Volcano, the Land of Ice, and a fifth machine on the Tongari Tower in West City. The machine in West City is protected by a powerful Energy Shield.
The Destron Gas is able to regenerate bodies of the ghost version of Frieza, Cooler, Lord Slug, Turles, and Dr. Raichi. another threat has invaded Earth; Destron Gas! In about 70 days, the entire Earth will die from it's effects! Now, it's up to Goku, Gohan, Piccolo, Trunks and Vegeta to save the Earth. They destroy several machines producing the gas and arrive back at West City where one of those is located. But they have company; Frieza! Shouldn't he have been killed by Trunks? And he's not the only one; Cooler and Turles are back as well, stronger than before! The z-fighters are shocked to see them but have no time for reunion as the villains attack! After fighting, our heroes start to suffer from the effects of the Destron Gas. Now, the villains have the upper the z-fighters are clearly outmatched. Having the side-effect from the Destron Gas affecting their fight, they are beaten. And even though the z-fighters manage to get few good hits, the villains are regenarated thanks to the Destron Gashand! Goku, Gohan and Trunks vegeta and piccolo are defeated and killed by the villains awesome new powers
The Destron Gas is featured in the Plan to Eradicate the Saiyans video game series, and also in the Story Mode of Dragon Ball Z: Super Butōden 2. In Super Butōden 2, Bojack and Zangya uses gigantic machines to spread the Destron Gas on Earth and get the Dragon Balls.